Since the C. elegans’ protein is similar to nervous system receptor proteins found in other species including humans, the discovery potentially brings scientists closer to finding ways to harness collagen expression to slow down human aging and increase lifespan in the midst of global warming. Led by scientists at Washington State University, the study was published in the journal Aging Cell. “Based on animal studies, scientists anticipate that human lifespan will go down in the future as climate change drives up the ambient temperature,” said senior author Yiyong (Ben) Liu, an assistant professor in the WSU Elson S Floyd College of Medicine and director of the university’s Genomics Service Centre. “We have found that warm temperatures leading to short lifespan is not a passive, thermodynamic process as previously thought, but a regulated process controlled by the nervous system. Our findings mean that down the road, it may be possible to intervene in that process to extend human lifespan as temperatures rise.”

The researchers looked at a nervous system protein known as NPR-8 in the tiny soil-dwelling worm Caenorhabditis elegans (C. elegans), a commonly used model organism in aging research. During their study, they observed that worms lacking NPR-8 had fewer skin wrinkles as they aged. They also made the unexpected discovery that mutant worms kept at a warm temperature of 25°C (77°F) had increased collagen expression and lived longer than wild-type worms, which did not happen when the worms were kept at 20°C or 15°C (68°F and 59°F, respectively). To determine whether the neural regulation of collagens may play a role in aging and longevity, they conducted a series of additional experiments and analyses.

“What we saw was that the absence of NPR-8 caused an increase in collagen expression, which increased the worms’ stress resistance and lifespan and made them look younger than wild-type worms that were the same biological age,” said co-first author Durai Sellegounder, a former postdoctoral research associate in the WSU Elson S Floyd College of Medicine who is now a scientist at the Buck Institute for Research on Aging.

In one experiment, the researchers reintroduced NPR-8 in mutant worms kept at 25°C and saw that this reverted the worms’ skin from smooth to wrinkled and significantly reduced the animals’ extended lifespan. Next, they showed that the extended lifespan of NPR-8 mutant worms also held up under heat stress conditions, with mutant worms surviving significantly longer than wild-type worms when moved into a 35°C (95°F) environment. Additional experiments identified specific neurons responsible for regulating lifespan in response to warm temperatures and pointed to increased expression of collagens as a driver of the improved lifespan at warm temperatures.#

Source: https://www.sciencedaily.com/